As some of my readers may have already gathered: I’m really excited about Martin Pall’s research findings. If you watched the last video, The NO/ONOO-Cycle, a New Disease Paradigm, by Pall, you’ll know there’s a heck of a lot of stuff there. From the latest gene testing for hereditary markers and gene mutations to balancing our supplements and getting control of our reactions, this is Science-based treatment, peeps:
Vicious (NO/ONOO-) cycle diagram: Each arrow represents one or more mechanisms by which the variable at the foot of the arrow can stimulate the level of the variable at the head of the arrow. It can be seen that these arrows form a series of loops that can potentially continue to stimulate each other. An example of this would be that nitric oxide can increase peroxynitrite which can stimulate oxidative stress which can stimulate NF-kappaB which can increase the production of iNOS which can, in turn increase nitric oxide. This loop alone constitutes a potential vicious cycle and there are a number of other loops, diagrammed in the figure that can collectively make up a much larger vicious cycle. The challenge, according to this view, in these illnesses is to lower this whole pattern of elevations to get back into a normal range. You will note that the cycle not only includes the compounds nitric oxide, superoxide and peroxynitrite but a series of other elements, including the transcription factor NF-kappaB, oxidative stress, inflammatory cytokines (in box, upper right), the three different forms of the enzymes that make nitric oxide (the nitric oxide synthases iNOS, nNOS and eNOS), and two neurological receptors the vanilloid (TRPV1) receptor and the NMDA receptor.
More from Martin Pall:
“These four illnesses, chronic fatigue syndrome (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and post-traumatic stress disorder (PTSD) often occur together in the same individuals (they are comorbid) and share many symptoms in common (1,2). They also share a common pattern of case initiation: Each is often initiated (that is started) by a short-term stressor only to be followed by chronic illness that typically lasts for years and most often for life. These various similarities and overlaps among these four have led many scientists to suggest that they may share a common aetiology (cause), however they have been uncertain what the cause may be. I will call these four illnesses multisystem illnesses, following the lead of some others, and will challenge here the claims they are unexplained and that even their symptoms are unexplained. What many have called the Gulf War Syndrome is a combination of all four.”
A Summary of Pall’s Hypothesis
The NO/ONOO- cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases.
Pall’s Research Publications include
- Pall M.L. (2007) Explaining “Unexplained Illnesses”: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromylagia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. Harrington Park (Haworth) Press, New York. Purchase from Nutri-Link
- Pall M.L. (2000) Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Med Hypotheses 54,115-125. View Abstract
- Pall M.L. (2001) Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 57,139-145. View Abstract
- Pall M.L. (2002) NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J 16,1407-1417. View Abstract
- Pall M.L. (2008) Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease. Med Hypotheses 71: 537-541. View Abstract
- Pall M.L. (2006) The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses: Etiology, explanation and effective therapy. In: New Research in Fibromyalgia, John A. Pederson, Ed., pp 39-59, Nova Science Publishers, Inc., Hauppauge, NY.
- Pall M.L., Anderson J.H. (2004) The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health 59,363-372. View Abstract
- Pall M.L., Satterlee J.D. (2001) Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. Ann N Y Acad Sci 933,323-329. View Abstract
- Pall M.L. (2009) The NO/ONOO- cycle mechanism as the cause chronic fatigue syndrome/myalgic encephalomyelitis. In: New Research in Chronic Fatigue Syndrome, John A. Pederson, Ed., Nova Science Publishers, Inc., Hauppauge, NY, in Press. View Abstract
- Pall M.L. (2009) Multiple chemical sensitivity: toxicological questions and mechanisms. Wiley & Sons, New York, in press.
(This information is credited to Professor Martin Pall, provided by Clinical Education.)