Glutathione Nasal Spray

After trying the NSP (which I’m taking a break from now), and a part of that being glutathione, I’ve found success with this. For a while I was taking the glutathione via capsules, then I started nebulising it, now I’ve moved onto the hard stuff: I’m taking it via a nasal spray that I bought from Custom Medicine. After purchasing it for a few months at around $45 for a month’s supply, plus $20 postage and handling, I decided to make my own. Although, I can tell you that the two batches I purchased from Custom Medicine, arrived in pristine condition: they were not contaminated by fragrance wearers, nor did they have any other type of contamination such as cleaners, or other medicines in it or on the packaging. (Custom Medicine make their products in a quality control lab, which you can see a picture of here.) (I’ll blog some more about other supplements I’ve purchased from here soon.)

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My specialist, Dr Colin Little, says of the treatments I often try, “So long as it does no harm.” And, even though taking this particular supplement is not causing me any obvious or noticeable harm, If I’m spending money on it while I’m trying to build a house, well, that kind of is doing me harm. That money could be better spent on our house, yes? So, in the interests of creating safe housing, that’s why I’ve started making my own glutathione nasal spray!

I’m not a doctor (obviously!), and I don’t recommend for any one else to make their own glutathione spray as there may be fallbacks to doing so. Some of the things I can think of: introducing infection into the sinuses; causing further inflammation of already inflamed areas; possible reaction to the glutathione (I’ve read about it irritating the nose lining.).

So without any further waffling on, I will share with you my method:

Materials

One nasal spray delivery bottle (If I had to replace the bottle I have, I’d buy a brand called Fess (it’s a saline spray), which I’d then tip out and reuse the bottle.)

Buffered glutathione (mine is from Theranaturals (who I’m in no way affiliated with))

Medical grade saline solution

(Important Notes:

I keep mine in the fridge as glutathione can undergo changes at room temperature

Also, I discard it and make a fresh batch after one month

I sterilise my delivery container with boiled water and saline between each batch; and I leave it to dry on the windowsill in sunlight before adding my concoction)

My Method

I take one sterilised nasal delivery bottle. Then I fill the bottle with medical grade saline solution. Next I open one full capsule of buffered glutathione and tip it into the bottle. I fasten the lid, then shake it. I leave this for a few minutes before use. And I store it in the fridge. (Using buffered glutathione is important because glutathione alone will burn the nasal lining. (Ouch, that’d hurt!))

Personal Use

I try to use this daily, however, when I’m well I have gone weeks without using it. I just can’t be bothered taking anything because I feel so good, I feel that I don’t need it (this recovery is only recent, before this, and for the last six months, I’ve been doing it daily).

I always, always, take it after a chemical exposure that has caused me harm. It’s possible, and I’ve mentioned this in another post, that it’s the saline solution that helps clear my sinuses, and helps rinse the fragrance, petrochemicals, or whatever else from my nasal cavity. Either way, it helps and I’m going to keep doing this one thing as part of my treatment plan.

Other Methods

There are many methods were you can get glutathione. Possibly the best, and smartest way would be from foods; particularly turmeric.

Rich Van Konynenburg, over at Phoenix Rising has complied some handy information on the variety of ways we can up our glutathione, and some suppliers of glutathione supplements. Thanks Rich!

List of suppliers for Liposomal Complex possibly suitable for environmentally sensitive people, here

More

Rich Van Konynenburg: Augmenting Glutathione in Chronic Fatigue Syndrome (ME/CFS)

The Labyrinth: More on Glutathione

The Labyrinth: Nebulising Glutathione 

The Environmental Illness Resource: What is the best way to raise Glutathione levels?

The Labyrinth: The NO/ONOO-Cycle, a New Disease Paradigm, by Martin L. Pall

The Labyrinth: Professor Martin Pall’s Research

 

 

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Nebulising Glutathione

This photograph is the vitamin container I bought from iHerb (I absentmindedly bought two, which it, serendipitously, turns out I can now plan out two weeks supplements in a row to save having to spend time each week counting out from all these bottles!); anyhow, it gives you an idea of how many supplements I’m taking each day. I’ve not counted but a wild guess would be twenty-seven or so capsules or tablets. I’ve been working up to doing the Neural Sensitisation Protocol (NSP) for more than a year. Finally, due to my budget allowing it, and my digestive and immune system tolerating it, I’m now practising this completely science-based treatment for people with chemical sensitivities.

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Back in 2009, when I was the Events Organiser for the AESSRA Chemical Sensitivity Seminar ’09, I received a phone call from a gentleman called Terry who, excitingly, shared that his wife had all but completely recovered while doing the NSP. She had similar symptoms within her upper respiratory system, including headaches, sinus and eye symptoms when inhaling chemical vapours, as to what I suffer with. Back then they were all the symptoms I had. (Unlike the past three years, where it’s been food intolerances, digestive issues, fatigue, sore joints and (almost) indescribable sinus pain.) And due to truly believing I’d almost recovered, I thanked Terry for telling me about this new treatment, printed out the documents he sent me, and forgot all about it.

Here is a part of the first page:

“Chemical injury can cause chronic damage to body biochemistry. This involves a biochemical vicious cycle often called “Neural Sensitization” (as discussed below). This cycle can cause reactive airways (airway inflammation), toxic encephalopathy (toxic brain damage), and chronic inflammation to other mucosal surfaces. This is chemically referred to as the nitric oxide/peroxynitrite cycle.1-4

Unless and until this biochemistry is healed naturally, inflammation and ongoing damage will occur. Drugs cannot heal these vicious cycles.

Only science-based treatment with the proper healing substances can help control this cycle, which will otherwise cause ongoing inflammation and further organ damage.”

I’ll upload the rest of the pages as PDFs in the next few days.

The nebulizing of buffered glutathione is one of the treatments I’ve instigated and facilitated as a part of my own wellness plan: this particular one is not under the care of a doctor; however, I didn’t just make it up! It’s a part of Dr Grace Ziem’s Neural Protocol on which she collaborated with Dr Martin Pall. Pall has developed a theory called the NO/ONOO cycle and its relation to oxidative stress, and its relation to conditions such as chemical sensitivity, Fibromyalgia, Chronic Fatigue Syndrome (CFS), heart disease and hypertension which can be found here.

This is the nebuliser that I bought of eBay for $20 plus postage and handling. I’m pretty impressed with its efficiency; it works surprisingly well for something that feels, looks and sounds like a cheap toy. (If you’re sensitive to plastics, I’d use this without the mask attached. It’s the soft squishy type of plastic and smells plasticky even after having been outgassing on my vitamin shelf for over a year. However, I’m fine with most plastics, though.)

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Back in January of this year, I wrote:

When I get sore eyes, it’s beyond painful, and I’ll try anything (almost); and obviously, I am. My nifty little nebuliser came off Ebay… The Glutathione tablets, which I bought from Theranaturals, cost twice more than the machine, itself. I don’t like nebulizing because it irritates the lining of my nose; consequently, I use only half a capsule, trying to build up to a whole capsule. Note: I only practice this technique after a chemical exposure when my upper respiratory system has taken a hit. The rest of the time I take the tablets because it’s easier and far less uncomfortable (People have told me that the body can’t absorb it this way.)

The jury in my mind is still out: we haven’t decided whether these methods, particularly the nebulisation of glutathione, are working or not. You see, when I’m in a room with people wearing a lot of fragrance, even when I’m wearing my hideous mask, my eyes sting, burn and feel as thought there’s fragrance in them; after a while I can also taste it, and my nostrils begin to burn, and that’s when I know I’m about to get really sick: massive throbbing headache, sore neck, and lately, swollen glands. For days. And then there’s the tiredness, which lasts longer now also. So, yeah, I’ll try just about anything. And yeah, I’ve been snorting Glutathione, hardcore. But only when I get sick.

Could it be that the mist helps clear my eyes or it could be the Glutathione?

I want it to be the glutathione. I want my NO/ONOO cycle to be totally interrupted. I want out of The Labyrinth

The jury in my mind have decided:

  • This treatment may help with inflammation of the upper respiratory system
  • It may also build up glutathione levels, thus allowing us ( ‘Us’ meaning you and I, not the jury in my mind (they’ve gone home now)) to handle, and recover from exposures better
  • Seeing I’ve been snorting inhaling a mist of glutathione each day, even when I’ve not been trying to recover from a chemical exposure, I’ve noticed that it no longer irritates my nasal passages, which means I can safely do it as a part of my daily supplement regime
  • The contents of Theranaturals L-Glutathione smells like a cross between sulphur from eggs and puppy farts; but that’s okay because I do believe it’s working! (I’ve blogged before about the type of symptoms (facial, sinus pain (on either side of my nose and my forehead, between and above my eyes), pulsating pain around in and around my eyes sockets that turn to bruises when relief is not found) I experience after breathing in traffic fumes, woodsmoke or fragrance, and how if this is coupled with mould exposure, it hurts to breathe even clean air—let alone an odour (natural or not!); this is still the case, however, my exposures have been far less since October last year, and thankfully, my physical reactions also. Ergo, on the days when I do have that type of pain I only take half a cap of L-Glutathione due to the pain caused when breathing in any odorous substance.)

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Also, readers of my blog have also pointed out to me in the past that taking Glutathione orally is a waste of time because the body can’t absorb it. Until I started hitting the nebuliser hardcore like a kid at a club, I’d always taken my glutathione in tablet form. People could have just told me that it’s just a way of expelling really expensive farts, but they didn’t (Too polite, I guess?!). So if you’re reading this and thinking of, or are already, taking glutathione orally, I’m telling you that the only thing it does is create really expensive farts! Trust me, I’m a wellness blogger and know this to be the truth; that’s why I’m sharing this with you.

I have a list of achievements, or rather improved markers of health, that I’ll share with you soon. I almost worry that if I blog about my health improvements I may jinx it. Kind of the opposite to magical thinking, you know? However, I’m just trying to keep a realistic view on things and do the best I can.

Due to recovering some quality of health back, I’d be ecstatic to share with you that this is the reason. However, I can’t, I refuse to hinge it on this one thing. The recovery is not huge but not being in pain 24/7, rather, only after mould/chemical exposures, does seem huge.

And I have to wonder, I am on my way out of The Labyrinth of Chemical Sensitivities?

More

PubMed: The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione

The Labyrinth: More on Glutathione (including other ways to get it)

The Labyrinth: Augmenting Glutathione

Martin Pall Lecture: The NO/ONOO-Cycle: A New Disease Paradigm

Martin Pall’s Research: Science Based Medicine

Peggy Munson: Myths and Facts About Chemical Sensitivity

All Photography copyright © Michellina van Loder 2015

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Professor Martin Pall’s Research

As some of my readers may have already gathered: I’m really excited about Martin Pall’s research findings. If you watched the last video, The NO/ONOO-Cycle, a New Disease Paradigm, by Pall, you’ll know there’s a heck of a lot of stuff there. From the latest gene testing for hereditary markers and gene mutations to balancing our supplements and getting control of our reactions, this is Science-based treatment, peeps:

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Vicious (NO/ONOO-) cycle diagram: Each arrow represents one or more mechanisms by which the variable at the foot of the arrow can stimulate the level of the variable at the head of the arrow. It can be seen that these arrows form a series of loops that can potentially continue to stimulate each other. An example of this would be that nitric oxide can increase peroxynitrite which can stimulate oxidative stress which can stimulate NF-kappaB which can increase the production of iNOS which can, in turn increase nitric oxide. This loop alone constitutes a potential vicious cycle and there are a number of other loops, diagrammed in the figure that can collectively make up a much larger vicious cycle. The challenge, according to this view, in these illnesses is to lower this whole pattern of elevations to get back into a normal range. You will note that the cycle not only includes the compounds nitric oxide, superoxide and peroxynitrite but a series of other elements, including the transcription factor NF-kappaB, oxidative stress, inflammatory cytokines (in box, upper right), the three different forms of the enzymes that make nitric oxide (the nitric oxide synthases iNOS, nNOS and eNOS), and two neurological receptors the vanilloid (TRPV1) receptor and the NMDA receptor.

More from Martin Pall:

“These four illnesses, chronic fatigue syndrome (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and post-traumatic stress disorder (PTSD) often occur together in the same individuals (they are comorbid) and share many symptoms in common (1,2).  They also share a common pattern of case initiation:  Each is often initiated (that is started) by a short-term stressor only to be followed by chronic illness that typically lasts for years and most often for life. These various similarities and overlaps among these four have led many scientists to suggest that they may share a common aetiology (cause), however they have been uncertain what the cause may be. I will call these four illnesses multisystem illnesses, following the lead of some others, and will challenge here the claims they are unexplained and that even their symptoms are unexplained.  What many have called the Gulf War Syndrome is a combination of all four.”

A Summary of Pall’s Hypothesis 

The NO/ONOO- cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases.

Pall’s Research Publications include
  1. Pall M.L.  (2007)  Explaining “Unexplained Illnesses”:  Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromylagia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others.  Harrington Park (Haworth) Press, New York. Purchase from Nutri-Link
  2. Pall M.L.  (2000)  Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.  Med Hypotheses 54,115-125. View Abstract
  3. Pall M.L.  (2001)  Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.  Med Hypotheses 57,139-145. View Abstract
  4. Pall M.L.  (2002)  NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity.  FASEB J 16,1407-1417. View Abstract
  5. Pall M.L.  (2008)  Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease.  Med Hypotheses 71: 537-541. View Abstract
  6. Pall M.L.  (2006)  The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses:  Etiology, explanation and effective therapy.  In:  New Research in Fibromyalgia, John A. Pederson, Ed., pp 39-59, Nova Science Publishers, Inc., Hauppauge, NY.
  7. Pall M.L., Anderson J.H.  (2004)  The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity.  Arch Environ Health 59,363-372. View Abstract
  8. Pall M.L., Satterlee J.D.  (2001)  Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.  Ann N Y Acad Sci 933,323-329. View Abstract
  9. Pall M.L.  (2009)  The NO/ONOO- cycle mechanism as the cause chronic fatigue syndrome/myalgic encephalomyelitis.  In:  New Research in Chronic Fatigue Syndrome, John A. Pederson, Ed.,  Nova Science Publishers, Inc., Hauppauge, NY, in Press. View Abstract
  10. Pall M.L.  (2009)  Multiple chemical sensitivity:  toxicological questions and mechanisms.  Wiley & Sons, New York, in press.

(This information is credited to Professor Martin Pall, provided by Clinical Education.)

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Information, products and views presented by guest bloggers @The Labyrinth are not necessarily the same as those held by this blog's author, Michellina van Loder. Reviews are my own personal opinions (unless stated otherwise); and satire is used throughout personal posts. Any health topics discussed are not to be taken as medical advice. Seek out medical attention if needed and do your own research; however, you're welcome to use mine as a start.
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