Nebulising Glutathione

This photograph is the vitamin container I bought from iHerb (I absentmindedly bought two, which it, serendipitously, turns out I can now plan out two weeks supplements in a row to save having to spend time each week counting out from all these bottles!); anyhow, it gives you an idea of how many supplements I’m taking each day. I’ve not counted but a wild guess would be twenty-seven or so capsules or tablets. I’ve been working up to doing the Neural Sensitisation Protocol (NSP) for more than a year. Finally, due to my budget allowing it, and my digestive and immune system tolerating it, I’m now practising this completely science-based treatment for people with chemical sensitivities.

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Back in 2009, when I was the Events Organiser for the AESSRA Chemical Sensitivity Seminar ’09, I received a phone call from a gentleman called Terry who, excitingly, shared that his wife had all but completely recovered while doing the NSP. She had similar symptoms within her upper respiratory system, including headaches, sinus and eye symptoms when inhaling chemical vapours, as to what I suffer with. Back then they were all the symptoms I had. (Unlike the past three years, where it’s been food intolerances, digestive issues, fatigue, sore joints and (almost) indescribable sinus pain.) And due to truly believing I’d almost recovered, I thanked Terry for telling me about this new treatment, printed out the documents he sent me, and forgot all about it.

Here is a part of the first page:

“Chemical injury can cause chronic damage to body biochemistry. This involves a biochemical vicious cycle often called “Neural Sensitization” (as discussed below). This cycle can cause reactive airways (airway inflammation), toxic encephalopathy (toxic brain damage), and chronic inflammation to other mucosal surfaces. This is chemically referred to as the nitric oxide/peroxynitrite cycle.1-4

Unless and until this biochemistry is healed naturally, inflammation and ongoing damage will occur. Drugs cannot heal these vicious cycles.

Only science-based treatment with the proper healing substances can help control this cycle, which will otherwise cause ongoing inflammation and further organ damage.”

I’ll upload the rest of the pages as PDFs in the next few days.

The nebulizing of buffered glutathione is one of the treatments I’ve instigated and facilitated as a part of my own wellness plan: this particular one is not under the care of a doctor; however, I didn’t just make it up! It’s a part of Dr Grace Ziem’s Neural Protocol on which she collaborated with Dr Martin Pall. Pall has developed a theory called the NO/ONOO cycle and its relation to oxidative stress, and its relation to conditions such as chemical sensitivity, Fibromyalgia, Chronic Fatigue Syndrome (CFS), heart disease and hypertension which can be found here.

This is the nebuliser that I bought of eBay for $20 plus postage and handling. I’m pretty impressed with its efficiency; it works surprisingly well for something that feels, looks and sounds like a cheap toy. (If you’re sensitive to plastics, I’d use this without the mask attached. It’s the soft squishy type of plastic and smells plasticky even after having been outgassing on my vitamin shelf for over a year. However, I’m fine with most plastics, though.)

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Back in January of this year, I wrote:

When I get sore eyes, it’s beyond painful, and I’ll try anything (almost); and obviously, I am. My nifty little nebuliser came off Ebay… The Glutathione tablets, which I bought from Theranaturals, cost twice more than the machine, itself. I don’t like nebulizing because it irritates the lining of my nose; consequently, I use only half a capsule, trying to build up to a whole capsule. Note: I only practice this technique after a chemical exposure when my upper respiratory system has taken a hit. The rest of the time I take the tablets because it’s easier and far less uncomfortable (People have told me that the body can’t absorb it this way.)

The jury in my mind is still out: we haven’t decided whether these methods, particularly the nebulisation of glutathione, are working or not. You see, when I’m in a room with people wearing a lot of fragrance, even when I’m wearing my hideous mask, my eyes sting, burn and feel as thought there’s fragrance in them; after a while I can also taste it, and my nostrils begin to burn, and that’s when I know I’m about to get really sick: massive throbbing headache, sore neck, and lately, swollen glands. For days. And then there’s the tiredness, which lasts longer now also. So, yeah, I’ll try just about anything. And yeah, I’ve been snorting Glutathione, hardcore. But only when I get sick.

Could it be that the mist helps clear my eyes or it could be the Glutathione?

I want it to be the glutathione. I want my NO/ONOO cycle to be totally interrupted. I want out of The Labyrinth

The jury in my mind have decided:

  • This treatment may help with inflammation of the upper respiratory system
  • It may also build up glutathione levels, thus allowing us ( ‘Us’ meaning you and I, not the jury in my mind (they’ve gone home now)) to handle, and recover from exposures better
  • Seeing I’ve been snorting inhaling a mist of glutathione each day, even when I’ve not been trying to recover from a chemical exposure, I’ve noticed that it no longer irritates my nasal passages, which means I can safely do it as a part of my daily supplement regime
  • The contents of Theranaturals L-Glutathione smells like a cross between sulphur from eggs and puppy farts; but that’s okay because I do believe it’s working! (I’ve blogged before about the type of symptoms (facial, sinus pain (on either side of my nose and my forehead, between and above my eyes), pulsating pain around in and around my eyes sockets that turn to bruises when relief is not found) I experience after breathing in traffic fumes, woodsmoke or fragrance, and how if this is coupled with mould exposure, it hurts to breathe even clean air—let alone an odour (natural or not!); this is still the case, however, my exposures have been far less since October last year, and thankfully, my physical reactions also. Ergo, on the days when I do have that type of pain I only take half a cap of L-Glutathione due to the pain caused when breathing in any odorous substance.)

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Also, readers of my blog have also pointed out to me in the past that taking Glutathione orally is a waste of time because the body can’t absorb it. Until I started hitting the nebuliser hardcore like a kid at a club, I’d always taken my glutathione in tablet form. People could have just told me that it’s just a way of expelling really expensive farts, but they didn’t (Too polite, I guess?!). So if you’re reading this and thinking of, or are already, taking glutathione orally, I’m telling you that the only thing it does is create really expensive farts! Trust me, I’m a wellness blogger and know this to be the truth; that’s why I’m sharing this with you.

I have a list of achievements, or rather improved markers of health, that I’ll share with you soon. I almost worry that if I blog about my health improvements I may jinx it. Kind of the opposite to magical thinking, you know? However, I’m just trying to keep a realistic view on things and do the best I can.

Due to recovering some quality of health back, I’d be ecstatic to share with you that this is the reason. However, I can’t, I refuse to hinge it on this one thing. The recovery is not huge but not being in pain 24/7, rather, only after mould/chemical exposures, does seem huge.

And I have to wonder, I am on my way out of The Labyrinth of Chemical Sensitivities?

More

PubMed: The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione

The Labyrinth: More on Glutathione (including other ways to get it)

The Labyrinth: Augmenting Glutathione

Martin Pall Lecture: The NO/ONOO-Cycle: A New Disease Paradigm

Martin Pall’s Research: Science Based Medicine

Peggy Munson: Myths and Facts About Chemical Sensitivity

All Photography copyright © Michellina van Loder 2015

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Professor Martin Pall’s Research

As some of my readers may have already gathered: I’m really excited about Martin Pall’s research findings. If you watched the last video, The NO/ONOO-Cycle, a New Disease Paradigm, by Pall, you’ll know there’s a heck of a lot of stuff there. From the latest gene testing for hereditary markers and gene mutations to balancing our supplements and getting control of our reactions, this is Science-based treatment, peeps:

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Vicious (NO/ONOO-) cycle diagram: Each arrow represents one or more mechanisms by which the variable at the foot of the arrow can stimulate the level of the variable at the head of the arrow. It can be seen that these arrows form a series of loops that can potentially continue to stimulate each other. An example of this would be that nitric oxide can increase peroxynitrite which can stimulate oxidative stress which can stimulate NF-kappaB which can increase the production of iNOS which can, in turn increase nitric oxide. This loop alone constitutes a potential vicious cycle and there are a number of other loops, diagrammed in the figure that can collectively make up a much larger vicious cycle. The challenge, according to this view, in these illnesses is to lower this whole pattern of elevations to get back into a normal range. You will note that the cycle not only includes the compounds nitric oxide, superoxide and peroxynitrite but a series of other elements, including the transcription factor NF-kappaB, oxidative stress, inflammatory cytokines (in box, upper right), the three different forms of the enzymes that make nitric oxide (the nitric oxide synthases iNOS, nNOS and eNOS), and two neurological receptors the vanilloid (TRPV1) receptor and the NMDA receptor.

More from Martin Pall:

“These four illnesses, chronic fatigue syndrome (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and post-traumatic stress disorder (PTSD) often occur together in the same individuals (they are comorbid) and share many symptoms in common (1,2).  They also share a common pattern of case initiation:  Each is often initiated (that is started) by a short-term stressor only to be followed by chronic illness that typically lasts for years and most often for life. These various similarities and overlaps among these four have led many scientists to suggest that they may share a common aetiology (cause), however they have been uncertain what the cause may be. I will call these four illnesses multisystem illnesses, following the lead of some others, and will challenge here the claims they are unexplained and that even their symptoms are unexplained.  What many have called the Gulf War Syndrome is a combination of all four.”

A Summary of Pall’s Hypothesis 

The NO/ONOO- cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases.

Pall’s Research Publications include
  1. Pall M.L.  (2007)  Explaining “Unexplained Illnesses”:  Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromylagia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others.  Harrington Park (Haworth) Press, New York. Purchase from Nutri-Link
  2. Pall M.L.  (2000)  Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.  Med Hypotheses 54,115-125. View Abstract
  3. Pall M.L.  (2001)  Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.  Med Hypotheses 57,139-145. View Abstract
  4. Pall M.L.  (2002)  NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity.  FASEB J 16,1407-1417. View Abstract
  5. Pall M.L.  (2008)  Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease.  Med Hypotheses 71: 537-541. View Abstract
  6. Pall M.L.  (2006)  The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses:  Etiology, explanation and effective therapy.  In:  New Research in Fibromyalgia, John A. Pederson, Ed., pp 39-59, Nova Science Publishers, Inc., Hauppauge, NY.
  7. Pall M.L., Anderson J.H.  (2004)  The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity.  Arch Environ Health 59,363-372. View Abstract
  8. Pall M.L., Satterlee J.D.  (2001)  Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.  Ann N Y Acad Sci 933,323-329. View Abstract
  9. Pall M.L.  (2009)  The NO/ONOO- cycle mechanism as the cause chronic fatigue syndrome/myalgic encephalomyelitis.  In:  New Research in Chronic Fatigue Syndrome, John A. Pederson, Ed.,  Nova Science Publishers, Inc., Hauppauge, NY, in Press. View Abstract
  10. Pall M.L.  (2009)  Multiple chemical sensitivity:  toxicological questions and mechanisms.  Wiley & Sons, New York, in press.

(This information is credited to Professor Martin Pall, provided by Clinical Education.)

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

The NO/ONOO-Cycle, a New Disease Paradigm, by Martin L. Pall

Today, I bring you this mind-riveting lecture on The NO/ONOO Cycle, a New Disease Paradigm from Professor Martin Pall, presented March 5, 2014 at the Bispebjerg Hospital in Copenhagen:

This is a 2.5 hour lecture by Dr. Martin Pall. Dr. Pall developed a protocol to correct problems with nitric oxide/peroxynitrite. His protocol overlaps quite a bit with the methylation protocols that many are familiar with, but has additional emphasis on nitric oxide, peroxynitrites, and antioxidants.

Dr. Pall believes NO/ONOO dysfunction lies at the heart of several disorders (heart disease, hypertension, fatigue syndrome, fibromyalgia, multiple chemical sensitivity, PTSD). Most of this lecture is a detailed explanation as to how these diseases relate to the NO/ONOO cycle.

I’ve [Judi Brooks] noted waypoints to save everyone time in accessing the video’s contents.

start……Intro to ideas and cycles
20:00…Downregulating cycle to reverse disease
25.38…Brief mention of systemic BH4 depletion
27:00…tendency for doctors to dismiss problems as psychological
29:40…treating cause rather than symptoms
30:45…34 mechanisms make up the NO/ONOO cycle, looking at heart disease
42.30…discussion of specific illnesses and how they relate to cycle

47:00…genetic basis of chronic fatigue (cortisol, ACE/angiotensin, inflammation, mitochondrial, superoxide)
50.30…testing his theory against new data (including BH4 depletion)
55.17…low BH4 in CFS, raised by sauna therapy
55.38…discusses GTPCH1 (i.e. GCH1), HSP90 protein and heat, sauna therapy
59.00…thalamus and cortisol and exercise
1.00.00…Saurez study on CFS and dramatic nitric oxide rise on exercise (rest!)

1.02.00…MCS pathways of action (pesticides, mercury), NMDA receptors
1.06.00…discussion of MCS, MSG sensitivity, CCK-B gene, dextromethorphan
1.09.30…Meggs study on inflammation, TRPV1 and TRPA1 receptors in MCS
1.11.00…Millqvist study on capsaicin, cough results in MCS
1.17.00…MCS genes (PON1 CYP2D6 NAT2 GSTM1 GSTT1 GSTP1 UGT1A1)
1.26.00…studies: Binkley’s CCK-B gene, Cui’s SOD-2 (superoxide dismutase)

1.35.00…discussion of Hetherington and Battershill, and rebuttal of criticisms

1.49.00…Electromagnetic hypersensitivity, microwaves, low-energy EMF fields
1.50.00…voltage-gated calcium channels; EMF opens cellular calcium channels
1.51.00…Released calcium causes effects; similarities between Ca & NDMA

1.54.00…Therapy ideas: 5-MTHF (methyfolate) as peroxynitrite scavenger
1.55.17…more on 5-MTHF; it increases methylation and lowers peroxynitrite
1.56.00…possible difficulty in tolerating high doses of 5-MTHF
1.58.00…high dose vitamin C helps 5-MTHF; 1 – 2.5g vit C will reduce ONOO
2.01.00…high vit C (1 – 2g) raises BH4 by converting BH3 back into BH4
2.02.00…IV vit C tried by some
2.03.10…hydrogen peroxide produced by IV vit C, may be anticancer in theory
2.04.00…H2O2 induces NRF2; as does zinc, curcumin, tocepherols (avoid alpha-tocepherol), silymarin, ellagic acid, green tea
2.06.00…sauna/heat’s main benefit may not be “detox” but by raising BH4
2.07.20…resveratrol raises SIRT1, which then raises BH4 and lowers superoxide, ONOO, and others
2.09.00…SIRT1 is NAD-dependent, but NAD is often low in NO/ONOO problem 2.09.14…take resveratrol with nicotinic acid (not nicotinamide) to raise NAD (Question: doesn’t nicotinic acid damage liver??)
2.11.00…use Mg-malate; magnesium deficiency increases NO/ONOO disease
2.13.00…omega-3 fatty acids; fish oil DHA and EPA;
2.14.00…cardiolipin, super oxide problem, heart failure
2.15.00…phosphlipids, phosphatidyl serine may go directly into mitochondria
2.16.00…L-carnitine and acetyl-l-carnitine help heart but may be mixed blessing
2.16.00…glutamate?
2.18.00…carotenoids useful, especially lycopene (tomatoes); activates NRF2
2:19.00…ending
2.20.00… addendum slides on carotenoids, phenolic and thiol antioxidants
2.20.12…addendum slide on sauna therapy, BH4, and GTPCH-1 (GCH1)
2.20.17…addendum slide on glutathione, riboflavin, niacin, NADPH; using high-dose thiamine to increase NADPH via the pentose phosphate shunt
2.20.24…addendum slide on vitamin E (tocopherols and tocotrienols); 12-lipoxygenase enzyme
2.20.31…addendum slide on high-dose B12. HyroxyB12 is a NO scavenger.

More

International Sholarly Research Articles: (The 44 distinct mechanisms that make up the NO/ONOO-Cycle) Pulmonary Hypertension Is a Probable NO/ONOO Cycle Disease: A Review

The Labyrinth: Glutathione Nasal Spray

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Information, products and views presented by guest bloggers @The Labyrinth are not necessarily the same as those held by this blog's author, Michellina van Loder. Reviews are my own personal opinions (unless stated otherwise); and satire is used throughout personal posts. Any health topics discussed are not to be taken as medical advice. Seek out medical attention if needed and do your own research; however, you're welcome to use mine as a start.
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