The NO/ONOO-Cycle, a New Disease Paradigm, by Martin L. Pall

Today, I bring you this mind-riveting lecture on The NO/ONOO Cycle, a New Disease Paradigm from Professor Martin Pall, presented March 5, 2014 at the Bispebjerg Hospital in Copenhagen:

This is a 2.5 hour lecture by Dr. Martin Pall. Dr. Pall developed a protocol to correct problems with nitric oxide/peroxynitrite. His protocol overlaps quite a bit with the methylation protocols that many are familiar with, but has additional emphasis on nitric oxide, peroxynitrites, and antioxidants.

Dr. Pall believes NO/ONOO dysfunction lies at the heart of several disorders (heart disease, hypertension, fatigue syndrome, fibromyalgia, multiple chemical sensitivity, PTSD). Most of this lecture is a detailed explanation as to how these diseases relate to the NO/ONOO cycle.

I’ve [Judi Brooks] noted waypoints to save everyone time in accessing the video’s contents.

start……Intro to ideas and cycles
20:00…Downregulating cycle to reverse disease
25.38…Brief mention of systemic BH4 depletion
27:00…tendency for doctors to dismiss problems as psychological
29:40…treating cause rather than symptoms
30:45…34 mechanisms make up the NO/ONOO cycle, looking at heart disease
42.30…discussion of specific illnesses and how they relate to cycle

47:00…genetic basis of chronic fatigue (cortisol, ACE/angiotensin, inflammation, mitochondrial, superoxide)
50.30…testing his theory against new data (including BH4 depletion)
55.17…low BH4 in CFS, raised by sauna therapy
55.38…discusses GTPCH1 (i.e. GCH1), HSP90 protein and heat, sauna therapy
59.00…thalamus and cortisol and exercise
1.00.00…Saurez study on CFS and dramatic nitric oxide rise on exercise (rest!)

1.02.00…MCS pathways of action (pesticides, mercury), NMDA receptors
1.06.00…discussion of MCS, MSG sensitivity, CCK-B gene, dextromethorphan
1.09.30…Meggs study on inflammation, TRPV1 and TRPA1 receptors in MCS
1.11.00…Millqvist study on capsaicin, cough results in MCS
1.17.00…MCS genes (PON1 CYP2D6 NAT2 GSTM1 GSTT1 GSTP1 UGT1A1)
1.26.00…studies: Binkley’s CCK-B gene, Cui’s SOD-2 (superoxide dismutase)

1.35.00…discussion of Hetherington and Battershill, and rebuttal of criticisms

1.49.00…Electromagnetic hypersensitivity, microwaves, low-energy EMF fields
1.50.00…voltage-gated calcium channels; EMF opens cellular calcium channels
1.51.00…Released calcium causes effects; similarities between Ca & NDMA

1.54.00…Therapy ideas: 5-MTHF (methyfolate) as peroxynitrite scavenger
1.55.17…more on 5-MTHF; it increases methylation and lowers peroxynitrite
1.56.00…possible difficulty in tolerating high doses of 5-MTHF
1.58.00…high dose vitamin C helps 5-MTHF; 1 – 2.5g vit C will reduce ONOO
2.01.00…high vit C (1 – 2g) raises BH4 by converting BH3 back into BH4
2.02.00…IV vit C tried by some
2.03.10…hydrogen peroxide produced by IV vit C, may be anticancer in theory
2.04.00…H2O2 induces NRF2; as does zinc, curcumin, tocepherols (avoid alpha-tocepherol), silymarin, ellagic acid, green tea
2.06.00…sauna/heat’s main benefit may not be “detox” but by raising BH4
2.07.20…resveratrol raises SIRT1, which then raises BH4 and lowers superoxide, ONOO, and others
2.09.00…SIRT1 is NAD-dependent, but NAD is often low in NO/ONOO problem 2.09.14…take resveratrol with nicotinic acid (not nicotinamide) to raise NAD (Question: doesn’t nicotinic acid damage liver??)
2.11.00…use Mg-malate; magnesium deficiency increases NO/ONOO disease
2.13.00…omega-3 fatty acids; fish oil DHA and EPA;
2.14.00…cardiolipin, super oxide problem, heart failure
2.15.00…phosphlipids, phosphatidyl serine may go directly into mitochondria
2.16.00…L-carnitine and acetyl-l-carnitine help heart but may be mixed blessing
2.16.00…glutamate?
2.18.00…carotenoids useful, especially lycopene (tomatoes); activates NRF2
2:19.00…ending
2.20.00… addendum slides on carotenoids, phenolic and thiol antioxidants
2.20.12…addendum slide on sauna therapy, BH4, and GTPCH-1 (GCH1)
2.20.17…addendum slide on glutathione, riboflavin, niacin, NADPH; using high-dose thiamine to increase NADPH via the pentose phosphate shunt
2.20.24…addendum slide on vitamin E (tocopherols and tocotrienols); 12-lipoxygenase enzyme
2.20.31…addendum slide on high-dose B12. HyroxyB12 is a NO scavenger.

More

International Sholarly Research Articles: (The 44 distinct mechanisms that make up the NO/ONOO-Cycle) Pulmonary Hypertension Is a Probable NO/ONOO Cycle Disease: A Review

The Labyrinth: Glutathione Nasal Spray

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Environmental Illness Websites from Around the World

More useful information from The Environmental Illness Network Minnesota via another great Listly list! This here, is a list of informative websites, blogs and support groups for people who are effected by chemicals. The good thing about these lists is that people can add information (in this case, MCS/Environmental Illness sites that they find useful) so that we can all benefit even further from these great resources; and, they can even embed these lists up on their own blogs. To do this, all you need is, if you are a WordPress user, the ‘Listly Plug-in‘, or just click on the ‘embed this list‘ button to find the Javascript code and to display it on your site today. It’s that easy! For more information about how to use Listly, click here.

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Environmental Illness Websites from Around the World

This is a list of websites, blogs, and social media groups that inform about, and/or support those who have, environmental illnesses. Vote for the websites that have been most helpful/informative for you. Environmental Illness Network Minnesota does not necessarily agree with the information and opinions found on any of these websites. This list should NOT be construed as a list of endorsements or recommendations.

AESSRA (Allergy and Environmental Sensitivity Support and Research Association Inc.) (An Australian Website)

AESSRA Inc. is a support group for people with allergies and sensitivities, particularly Multiple Chemical Sensitivity (MCS). It started in Melbourne and now has members around Australia.

Mar 07, 2013 - allergictolifemybattle.wordpress.com - 225
allergictolifemybattle (A Wordpress Blog)

"After exposure to severe mold in the workplace, I found myself unable to continue the life I once led. I was forced to quit work and give up many things that I cherised. At the time I became ill, I was a 45-year-old mother of two."

A.M.I.C.A. (An Italian Website)

"A.M.I.C.A. – Association for Environmental and Chronic exposure injury – was founded the 21st of May 2003 by a group of chemically injured people and their relatives, with the aim of promoting the knowledge and the awareness about the health problems caused by exposure to chemicals in the Environment and in Consumer products."

Nov 23, 2012 - envirn.org - 291
ANHE: Alliance of Nurses For Healthy Environments

"The Mission of ANHE: Promoting healthy people and healthy environments by educating and leading the nursing profession, advancing research, incorporating evidence-based practice, and influencing policy."

Nov 24, 2012 - annelipscomb.com - 243
Anne Lipscomb's Blog (Paris & Seattle)

"I hope my story of overcoming adversity will help you to triumph over your own adversity and overcome any obstacle that may show up in your own path."

Aug 11, 2014 - annmccampbell.com - 258
Ann McCampbell, M.D.

"Dr. McCampbell is currently Chair of the MCS Task Force of NM and a board member of the Chemical Sensitivity Foundation."

An Organic Place to Live (a US Blog)

A blog about Environmental Illness, Toxins, Mold and Self Help

Nov 21, 2012 - citlink.net - 285
Artists with Multiple Chemical Sensitivity

"The Artists with MCS network was founded by Moon McNeill, a painter and an author from Germany, in August 2001. She suffered from a lack of information about safe materials and the possibilities of continuing to work as an artist after her MCS-diagnosis. After a long and difficult period of reorientation, she found that the arts are not only the perfect medium to express MCS-specific content, but art could also give a new perspective to lives damaged by environmental illness. Art is therapeutic in itself. On top of that, the founder soon realized that more artists with MCS seemed to be waiting for such a group. Now, she is accompanied by a growing number of German and American painters, musicians, filmmakers, sculptors, videoartists and authors, some of them well known."

ASEHA QLD (An Australian Website)

"ASEHA (Allergy, Sensitivity & Environmental Health Association Qld Inc) is a voluntary organisation, it is a self-help support group for people with allergy, food intolerance, multiple chemical sensitivity, chronic fatigue syndrome/Fibromyalgia, hyperactivity, attention deficit disorder. ASEHA was formed in 1984 to bring allergy sufferers together to share information, for encouragement and mutual support."

ASEQ_EHAQ Environmental Health Association of Québec (A Canadian Website)

"The Mission of the Environmental Health Association of Québec (ASEQ-EHAQ) is the protection of the environment and human health directed towards the individual and the collective by creating awareness, support and education of the population on the protection of the environment from toxic products and pesticides."

ASSSEM Asociación de Sanitarios al Servicio de Encefalomielitis Miálgica-Síndrome de Fatiga Crónica (A Spanish Website)

"¿Qué es ASSSEM? Es una organización independiente y sin ánimo de lucro, formada en su mayor parte por profesionales sanitarios, cuyo objetivo principal es mejorar el grado asistencial de un colectivo de enfermos que padecen patologías graves y poco reconocidas como son el Síndrome de Fatiga Crónica-Encefalomielitis Miálgica (SFC-EM), la Fibromialgia (FM) y el Síndrome Químico Múltiple ( SQM), que padecen alrededor del 3 % de la población general con gran afectación a diferentes niveles."

Nov 23, 2012 - goodreads.com - 254
Canary Connections Group (on Goodreads)

"books for and about people with multiple allergies; environmental / chemical illness; or food sensitivities, allergies, or intolerance."

CFCCC: Chronic Fatigue Syndrome, Fibromyalgia, & Chemical Sensitivity Coalition of Chicago

"CFCCC is organized for the purposes of support, education, and advocacy for persons with chronic fatigue syndrome, fibromyalgia, and chemical sensitivity."

Jun 17, 2013 - cfsfmmcschirps.tumblr.com - 227
CFS, FM, & MCS (on Tumblr)

"My name is Laurie. I have Hashimoto’s thyroiditis, chronic fatigue syndrome, and multiple chemical sensitivities. Shortly after I first got sick, my aunt, a nurse anesthetist, insisted I learn how to read the medical studies. She had handed me a huge medical school dictionary and a few studies and told me I was going to learn as much as I could because I had something with no answers."

Chemical Injury Books Group (on Goodreads)

"I know some of us who have been injured by toxins in the environment need a group where we can find books that will help us to get well or figure out how to avoid more toxic injuries."

Nov 21, 2012 - ciin.org - 299
Chemical Injury Information Network (A US Website)

"The Chemical Injury Information Network (CIIN) is a non-profit, charitable support and advocacy organization run by the chemically injured for the benefit of the chemically injured."

Aug 11, 2014 - chemicalsensitivity.com - 239
Chemical Sensitivity

"Providing current news and information regarding Multiple Chemical Sensitivity and related conditions. We also offer a forum and an e-store filled with fragrance-free, hypoallergenic and natural products."

CHEMSENSE (A Virgnia, Maryland, & DC Website)

"CSDA - MCS EI Group in Virginia, Maryland and DC. Health resource and support for chemically poisoned. Chemsense - chemical sensitivity and common sense"

Chemsense - Chemical Sensitivity Disorders Association - Support for Chemically Sensitive, MCS in Maryland, D.C. and VA

"Chemical Reaction Support CSDA Metro-Wide Group Do you react to common chemicals, such as perfume, petrochemicals, carpeting? A support group meets occasionally in Maryland and Northern Virginia sharing information on everyday toxins, helpful advice, and social support. The CSDA (Chemical Sensitivity Disorders Association) is a national group with many members in Virginia and Maryland."

Cleaner Indoor Air Campaign (U.S.)

"CIAC provides information about Environmental Illnesses such as Multiple Chemical Sensitivities (MCS), Toxic Injury, Chemical Injury and/or Toxic Encephalopathy, as well as chemicals and fragrances in everyday products and resources.

CIAC also provides helpful tools such as letters and posters for people to use to make changes in their community businesses, medical facilities and churches."

Nov 22, 2012 - csn-deutschland.de - 258
CSN - Chemical Sensitivity Network (A German Website)

"CSN bietet Betroffenen und Interessierten ausführliche Informationen rund um die Themen Chemikalien-Sensitivität und Umweltkrankheiten."

Nov 24, 2012 - danallenfoundation.com - 295
Dan Allen Foundation (A US Website)

"The Dan Allen Foundation was founded for the purpose of raising awareness of Multiple Chemical Sensitivity Disorder (MCS) and similar neurological disorders caused by exposure to environmental toxins, chemicals, and pollutants. "

Detox your Body

"This website is about how to detox the body and be healthy as economically and easily as possible... I write daily posts for Facebook, Twitter and have many videos on YouTube. Don’t forget, I’m not a doctor or a nutritionist, and this is just my own experience."

Apr 13, 2013 - drsteinemann.com - 272
Dr. Anne Steinemann (A U.S. Website)

"Dr. Anne C. Steinemann is an internationally recognized expert on pollutant exposures and associated health effects, including topics of indoor air quality, consumer product testing and evaluation, exposure assessment, and healthy homes and communities."

Nov 24, 2012 - drclaudiamiller.com - 288
Dr. Claudia S. Miller's Blog

"Claudia Miller, M.D., M.S. is a tenured Professor in Environmental and Occupational Medicine and Vice Chair of the Department of Family and Community Medicine of the University of Texas Health Science Center at San Antonio (UTHSCSA). She is also founder and director of the South Texas Environmental Education and Research (STEER) Program, the only medical school curriculum to offer hands-on, experiential training in environmental health, public health, and international health at the US-Mexico border. STEER has been the recipient of national and state awards for excellence in environmental and medical training."

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

MedicAlert ID, Chemical Sensitivity and MCS

 

Swarkovski Crystal MedicAlert bracelet

This here is my Medicalert bracelet. My new one that is. In 2009, I threw away my old one because I had recovered so much that I did not see being exposed to chemicals as a threat to my health because I wasn’t having painful, life impacting symptoms. And I just didn’t see the need for it. As soon as my health improved I stopped paying my yearly fee, and stopped wearing the bracelet: it was a plain stainless steal emblem attached to a black velcro sports band. However, ugly fugly that it was, it would have still done the job of identifying the chemicals that I was sensitive to, and told the medical staff what treatment I needed; and it created a feeling of safety whenever I left my home. I threw it out when I left the farm house, we were living at, and moved back to the city. In some ways, I feel totally stupid believing that I was cured. But if it… when it happens again, I’ll still believe I’m well/cured because it’s a great state of mind to be in. Who’d want to hang onto the idea of being sick, especially once you have the freedom to do almost whatever you want? (Hence throwing the MedicAlert bracelet away.) Yes, maybe that oh-I’m-so-fuckin-cured-now state made me behave in ways that caused me to get sick again. So, next time, I’ll be more careful; I’ll never go back to using a whole lot of chemicals again/or living near mould, because I’m living proof that they can build up in the body and cause a relapse (or effect the immune system, thus causing sensitisation to them—which ever theory works for you)!

My condition is now worse than it’s ever been, and I’d forgotten all about the bracelet until I saw this post over Lindsay’s blog, Musings of a Dysautonomiaca friend of Rachel’s over at doilooksick, and of author’s, Kathryn Treat over at allergictomylifemybattle, and I realised that that was exactly what I needed to help me feel more confident when going out and leaving my home: all these people have invisible illnesses. (So, thanks to those lovelies!) And, I can’t say that one illness is more serious than another, but I can say that anyone who has an illness that’s invisible, absolutely needs one of these babies!

I’m lucky, I have knowledgable doctors and specialists, and if there ever was a medical emergency, I’d certainly want anybody who was medically assisting me to have these guy’s input, and I’d need them to advise medical staff. And I’d want any medical staff who were treating me to actually treat me without harming me. It’s no biggie really; but if they don’t know that I’m chemically sensitive, and I can’t tell them, then it could cause a massive problem for me. (And, now that we have the Hospital Guidelines for people who are sensitive to chemicals or have MCS, the process is a lot clearer. For staff and for me. I used to be scared to go to a hospital; I’m not now because I know there is a formula for all medical attendants to follow.)

If you have a medical condition that causes you to wonder that, in the realm of all freaky, unknown possibilities, if something were to go wrong, how would  medical staff know certain things? Then you may need one of these gorgeous little jewels to help you chill out a bit.

This is what’s on my emblem:

CHEMICAL

SENSITIVITIES:

PERFUME, SOLVENTS,

VEHICLE EXAUST.

(WEARS MASK)

On the emergency card that I carry in my wallet, and another that lives stuck to my fridge, it says:

(The same as above +): Medical Conditions: chemical sensitivity, associated with sinus, eyes, upper respiratory symptoms, dry eyes, headache, nausea and musculoskeletal system.

Allergies: (Here the list gets longer because there is more room): Sensitive to moulds, perfumes, nitrogen dioxide, vehicle emissions, wood smoke, and inhaled allergens (and some medications, which I’ve omitted from here).

Medications: (In here are the Medicines and supplements that I take) Wears a mask and avoids chemicals to which she is sensitive to.

Other information: Please refer to the Multiple Chemical Sensitivity (MCS) Hospital guidelines and the links as noted in ‘other notes’

See that bit above about the MCS Hospital Guidelines? I gave the MedicAlert people a hardcopy to keep on file, which makes me feel secure in the knowledge that I will be treated with the appropriate care.

(The links to where they are kept on the web are also on file. Except the Victorian Government archived them, asking people to use the contact form to request a copy; so I asked them nicely to please put them back up because people can’t email and wait for this important document in an emergency! So that’s why I ended up printing a copy and posted them in to go on my file. You, too could do this. (And yes, the lovely people working for the Victorian Government put them back up!)

Now, here is something to confuse to you, I’m not sure… Even though I titled this post ‘MedicAlert and MCS’, I don’t identify as having Multiple Chemical Sensitivity (MCS), although my symptoms are the same, the treatment is the same, and so are the things that improve my health after an exposure (exactly the same as compared to an individual with MCS) and all of these are exactly the same as those for MCS.

What is Multiple Chemical Sensitivity (MCS)? 

Here’s an extract from Allergy and Environmental Sensitivity Support and Research Association Inc.(AESSRA), Australia’s number one association for chemical sensitivities and MCS:

The 1999 Consensus Statement criteria for Multiple Chemical Sensitivity (MCS) are:

1. The symptoms are reproducible with (repeated chemical) exposure.
2. The condition is chronic.
3. Low levels of exposure (lower than previously or commonly tolerated) result in manifestations of the syndrome.
4. The symptoms improve or resolve when the incitants are removed.
5. Responses occur to multiple chemically unrelated substances.
6. Symptoms involve multiple organ systems.(2)

I don’t identify as having MCS because nowhere in any of my files is it written down by my treating doctors as ‘MCS’: two specialists have it down as chemical sensitivities to various chemicals, and my GP calls it chemical allergies. The two specialists that I see, even say that it has different causes: one specialist says it’s an immunological response (like an allergy but the mechanisms are different) and avoidance of chemicals is key; and the other one says it’s partly that, but it’s also the body becoming over toxified, therefore, it’s a toxicological response, and the body is depleted of vitamins and nutrients, and that avoiding chemicals entirely is not good because the body cannot build it’s own resistance/immunity up (this doctor does not support me going out and getting sick from exposures, he just thinks that 100% isolation is detrimental in the long run!). Two completely different ideas. Two different treatments. Same diganosis. I don’t care which one is right, and both doctors have helped me immensely over the years; so when I got better, I could not pin point what exactly helped me… and it didn’t matter then, not so much as what it does now (cause I’d really like to know this curing factor!). So with a multi-pronged approach and baby steps I’m following the same path, including covering my but with a Medicalert bracelet!

So I don’t have MCS, but I wan’t to be treated like I have MCS? Confused much?

MCS is a recognised, diagnosable condition in many countries overseas (GermanyDenmarkSwedenJapan). It does exist. And in the US, and in Canada it’s recognised as a disability. In Australia it is too. But it’s not recognised by the Australian Medical Association as a medical condition—as yet. (And this would be because of the two examples above: doctors don’t agree on the cause, or the treatment.) So I can’t go talk to a doctor I don’t know, and say that I have some illness that he says he doesn’t understand cause it’s not in his medical book. And I can’t it because then it’s my job to explain it to him, even though I have no proof to support that I have it. I can’t and I won’t put myself through that. (I know, I should just take one for the team and walk around saying: “I have MCS.” But I need to get on with my life. I need to go to Uni. I need/want to get work one day. And I need to have people understand me because I need their support.) However, I can say that I have chemical sensitivities (which is my diagnosis but it’s not an actual disease or a condition); and if people don’t understand about chemical sensitivities, then I can say I have chemical allergies or  inhalant allergies, and I can produce a lot of proof via testing and treatments and doctor’s letters that show, yes, I have chemical sensitivities/or ‘allergies’ and need to be treated as such. And, yes, it’s a disability and (sometimes) needs to be treated as such. But if I ever go to the hospital, I want to be treated as if I have MCS…

So that’s why my MedicAlert bracelet says ‘Chemical Sensitivities’. Get it?

Don’t you just love my new MedicAlert bracelet? Haven’t they changed over the years?

~

Just for you: MedicAlert Links

MedicAlert Australia

MedicAlert US

MedicAlert Canada

MedicAlert South Africa

MedicAlert UK

~

More Bloggers and MedicAlert:

The Food Allergy Chronicles

Musings of Disautonomiac

DysGirl

Disorderly Chickadee

Food Allergy Kitchen

allergictomylifemybattle

~

Iphone App

The iPhone app, ICE 123, that holds emergency information (thanks be to doilooksick for this info) for people who don’t want to wear an ID bracelet:

– Free! Full features like the paid version (Except camera & full health description view)
– Make family cards
– Customize ICE labels

*** It is a normal practice for Police, Fire & Paramedic personals to call the phone owner’s near & dear relations in case of emergencies.

*** In Emergency Situations, your senses never work, but your iPhone can help you.

For more information, click here

~

 Allergy Wristbands Australia

Allergy Wristbands for children and adults

Cheers

Here’s to never going to hospital, ever. And the only point of this post only ever being to help someone else!

x

Update (February 2013)

Have you seen the new Australian MediAlert community service advertisement (CSA) on free-to-air television or on Foxtel in recent weeks? If you haven’t, click here or to see an extended version click here or watch the extended version below (the shorter version has far more impact, as it’s dramatic, it makes you feel awful for the actors even though it’s not real life (I got all emotional).

If you have a MedicAlert Bracelet, here is some information about updating your details.

Michellina Van Loder is a Professional Writer, Journalist and Blogger. This is where she shares her tales about trail blazing her way out of the Labyrinth of Chemical Sensitivities and Mould. This is also where you will find the latest Research on related topics.

Information, products and views presented by guest bloggers @The Labyrinth are not necessarily the same as those held by this blog's author, Michellina van Loder. Reviews are my own personal opinions (unless stated otherwise); and satire is used throughout personal posts. Any health topics discussed are not to be taken as medical advice. Seek out medical attention if needed and do your own research; however, you're welcome to use mine as a start.
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